Micardis is used to treat essential hypertension high blood pressure in adults. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Micardis is available as white or off-white, uncoated tablets containing telmisartan 20 mg, 40 mg, or 80 mg. Tablets are marked with the BOEHRINGER INGELHEIM logo on one side, and on the other side, with either 50H, 51H, or 52H for the 20 mg, 40 mg, and 80 mg strengths, respectively.
My doctor agreed because my blood pressure went down. High blood pressure makes the heart work harder to pump blood throughout the body and causes damage to the blood vessels. If high blood pressure is not treated, it can lead to stroke, heart attack, heart failure, kidney failure, and vision problems. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal. Salt-Depleted Patients under Dosage and Administration. Importance of informing patients of other important precautionary information. 1 2 See Cautions. Micardis HCT contains a sulfonamide called hydrochlorothiazide, which can cause certain eye problems myopia, angle-closure glaucoma. Your risk may be increased if you are allergic to sulfonamide medicines eg, sulfamethoxazole or to penicillin antibiotics eg, amoxicillin. Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting Micardis HCT. Contact your doctor immediately if you experience symptoms, such as vision changes eg, decreased vision clearness or eye pain.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Fagundes Neto U, Franco L, Tabacow K, Machado NL. Negative findings for use of coconut water as an oral rehydration solution in childhood diarrhea. Some MEDICINES MAY INTERACT with Micardis HCT. You may take telmisartan with or without food.
What should I tell my doctor before taking Micardis tablets? As a consequence of inhibiting the renin-angiotensin-aldosterone system, anticipate changes in renal function in susceptible individuals. American Diabetes Association. Standards of medical care in diabetes--2014. Diabetes Care. Concomitant use of telmisartan and aliskiren in patients with diabetes mellitus. a 550 See Specific Drugs under Interactions. If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Micardis HCT. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Tell your doctor if you develop any new symptoms. Can use the fixed combination as a substitute for the individually administered drugs. 132 Can switch to the fixed-combination preparation containing the corresponding individual doses of telmisartan and amlodipine; alternatively, can increase the dosage of one or both components for additional antihypertensive effects. The medicine can only be obtained with a prescription. How is Micardis used? If adequate BP response not achieved with a single antihypertensive agent, add a second drug with demonstrated benefit; if goal BP still not achieved with optimal dosages of 2 antihypertensive agents, add a third drug. 501 May maximize dosage of the first drug before adding a second drug, or add a second drug before maximizing dosage of the initial drug. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Slowly titrate dosage in patients with severe renal impairment. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Micardis as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus.
Hypotension may be more common in patients receiving Micardis to prevent cardiovascular problems. For the full list of all side effects reported with Micardis, see the package leaflet. Effect of losartan on renal and cardiovascular complications of patients with type 2 diabetes and nephropathy. You may also need to avoid taking hydrochlorothiazide and telmisartan with aliskiren if you have kidney disease. The dosage is based on your medical condition and response to treatment. Micardis HCT may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Metabolized in liver via conjugation to inactive metabolite. PREGNANCY and BREAST-FEEDING: Micardis HCT may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Micardis HCT is found in breast milk. Do not breast-feed while taking Micardis HCT. Brenner BM, Cooper ME, de Zeeuw D et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. Micardis HCT may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Tiredness and may also occur. If any of these effects persist or worsen, tell your doctor or promptly. If your symptoms do not improve or if they become worse, check with your doctor. There is also an AT 2 receptor found in many tissues, but AT 2 is not known to be associated with cardiovascular homeostasis. Hg is 26, 22, or 55% with telmisartan 80 mg daily alone, amlodipine 10 mg daily alone, or telmisartan combined with amlodipine same dosages respectively. metaglip
Should not be used in these patients. Use Micardis HCT with caution in the ELDERLY; they may be more sensitive to its effects. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Micardis is a non-peptide angiotensin II receptor type AT 1 antagonist. In rare cases, hydrochlorothiazide and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. When used for initial therapy of hypertension in patients likely to require combination therapy with multiple antihypertensive agents, usual initial dosage is telmisartan 40 mg and amlodipine 5 mg once daily; initial dosage of telmisartan 80 mg and amlodipine 5 mg once daily may be used in patients requiring larger BP reductions. Lab tests, including kidney function, blood pressure, and blood electrolytes, may be performed while you use Micardis HCT. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. American Heart Association Task Force on Practice Guidelines. Circulation. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure JNC V. Arch Intern Med. labl.info pyridium
If you have heart failure, talk to your doctor before you take any supplement. There's no strong evidence that vitamins or other can help treat heart failure. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. The information contained in the Truven Health Micromedex products as delivered by Drugs. In the prevention of cardiovascular problems, Micardis had a similar effect to ramipril, with around 17% of patients dying, being admitted to hospital because of cardiovascular problems, or having a heart attack or stroke. The combination of the two medicines was no more effective than either medicine taken alone and was linked to an increased risk of side effects. What is the risk associated with Micardis? Lewis EJ, Hunsicker LG, Bain RP et al. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med. Its empirical formula is C 33H 30N 4O 2, its molecular weight is 514. Your doctor may direct you to start taking the individual medications first, and then switch you over to this combination product if this is the best dose combination for you.
In the treatment of essential hypertension, Micardis was more effective than placebo at reducing diastolic blood pressure and had similar effects to the other medicines for hypertension. FDA pregnancy category D. Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Hydrochlorothiazide and telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control. Liver Enzymes: Occasional elevations of liver chemistries occurred in patients treated with telmisartan; all marked elevations occurred at a higher frequency with placebo. No telmisartan-treated patients discontinued therapy because of abnormal hepatic function. Frohlich ED. Recognition of systolic hypertension for hypertension. Hypertension. Some telmisartan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. The antihypertensive effect of angiotensin II receptor antagonists, including telmisartan may be attenuated by NSAIDs including selective COX-2 inhibitors. Micardis can cause harm or death to an unborn baby. Talk to your doctor about other ways to lower your blood pressure if you plan to become pregnant. If you get pregnant while taking Micardis, tell your doctor right away. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Telmisartan: Initiate therapy under close medical supervision in patients with obstructive biliary disease or hepatic impairment. When used in fixed combination with amlodipine or hydrochlorothiazide, consider the cautions, precautions, and contraindications associated with the concomitant agent. Who should not take Micardis? What is the most important information I should know about Micardis tablets? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Importance of instructing patients not to remove tablets from the blister package until immediately before administration. Food and Drug Administration. FDA drug safety communication: ongoing safety review of the angiotensin receptor blockers and cancer. Rockville, MD; 2010 Jul 15. From FDA website. buy protopic-ointment houston
Micardis tablets 20 mg are round and individually blister-sealed in cartons of 30 tablets as 3 x 10 cards NDC 0597-0039-37. Izzo JL, Levy D, Black HR. Importance of systolic blood pressure in older Americans. Hypertension. Danish; with English abstract. Not removed from blood by hemofiltration. Dosage of Micardis is individualized. The usual starting dose is 40 mg once a day. Micardis may interact with water pills or digoxin. Tell your doctor all medications you are taking. Micardis is not recommended for use during pregnancy due to the risk for harm to a fetus. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding. Larger doses up to 160 mg did not appear to cause a further decrease in blood pressure. price nitrofurantoin generic
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For individual components of the primary composite endpoints, all events, regardless whether or not they were the first event, were considered. Therefore, they are more than the first events considered for the primary or secondary composite endpoint. Do not co-administer aliskiren with Micardis in patients with diabetes. McClellan KJ, Markham A. Telmisartan. Drugs. Studies of telmisartan in this setting do not exclude the possibility that telmisartan may not preserve a meaningful fraction of the effect of the ACE inhibitor to which it was compared. Consider using the ACE inhibitor first, and, if it is stopped for cough only, consider re-trying the ACE inhibitor after the cough resolves. vidalta
Food and Drug Administration. FDA drug safety communication: No increase in risk of cancer with certain blood pressure drugs-angiotensin receptor blockers ARBs. Rockville, MD; 2011 Jun 2. Available from FDA website. Micardis is indicated for reduction of the risk of myocardial infarction, stroke, or death from cardiovascular causes in patients 55 years of age or older at high risk of developing major cardiovascular events who are unable to take ACE inhibitors. Do not share this medication with others. Check with your pharmacist about how to dispose of unused medicine. This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.
In placebo-controlled trials involving 1041 patients treated with various doses of Micardis 20 to 160 mg monotherapy for up to 12 weeks, the overall incidence of adverse events was similar to that in patients treated with placebo. CPK, anaphylactic reaction, tendon pain including tendonitis, tenosynovitis drug eruption toxic skin eruption mostly reported as toxicoderma, rash, and urticaria hypoglycemia in diabetic patients and angioedema with fatal outcome. Food slightly reduces bioavailability. Three studies examined the use of CoQ10 along with conventional treatment for cancer. JATOS Study Group. Principal results of the Japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients JATOS. Hypertens Res. celecoxib
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.